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Marburg Virus Disease (MVD):
✅It is a rare but
severe hemorrhagic fever which affects both people and non-human primates.
✅ It is caused by the
Marburg virus, a genetically unique
zoonotic (or, animal-borne)
RNA virus of the
filovirus family.
It is in the
same family as the virus that causes the
Ebola virus
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Transmission:
✅Human infection with MVD initially results from prolonged
exposure to mines or caves inhabited by Rousettus bats.
✅Once an individual is infected with the virus, Marburg can spread through
human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials (e.g., bedding, clothing) contaminated with these fluids.
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Symptoms:
✅After an
incubation period of 2-21 days, symptom onset is sudden and marked by fever, chills, headache, and myalgia.
✅
Around the fifth day after the onset of symptoms, a
maculopapular rash, most prominent on the trunk (chest, back, stomach), may occur.
✅
Nausea, vomiting, chest pain, a sore throat, abdominal pain, and
diarrhea may appear.
✅Symptoms
become increasingly severe and can include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, massive hemorrhaging, and multi-organ dysfunction.
✅The
average MVD case
fatality rate is
around 50%. Case fatality rates have varied from 24% to 88% in past outbreaks, depending on the virus strain and case management.
✅There is
no specific treatment for MVD. Early supportive care with rehydration, and symptomatic treatment improves survival.
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